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4 edition of Characterization of a novel INK4A/ARF transcript found in the catalog.

Characterization of a novel INK4A/ARF transcript

Ockert Johannes Fourie

Characterization of a novel INK4A/ARF transcript

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Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 2002.

SeriesCanadian theses = -- Th`eses canadiennes
The Physical Object
FormatMicroform
Pagination1 microfiche : negative.
ID Numbers
Open LibraryOL19897624M
ISBN 10061274051X
OCLC/WorldCa54206053

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and basic research have. Moore L, Holmes K, Smith S, Wu Y, Tchougounova E, Uhrbom L, Sawaya R, Bruner JM, Fuller GN, Zhang W. IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas. Proc Natl Acad Sci (39), Recommend Documents. No documents. Epigenetics and Dermatology.


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Characterization of a novel INK4A/ARF transcript by Ockert Johannes Fourie Download PDF EPUB FB2

P14ARF (also called ARF tumor suppressor, ARF, p14 ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein).

It accumulates mainly in the nucleolus where it forms stable complexes with NPM or howtogetridofbadbreath.club: PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around).

It has been shown that when FAK was blocked, breast cancer cells Aliases: PTK2, FADK, FAK, FAK1, FRNK. Novel frameshift mutation in the p16/INK4A tumor suppressor gene in canine breast cancer alters expression from the p16/INK4A/p14ARF locus Article in Journal of Cellular Biochemistry · January.

Abstract. Coronins have maintained a high degree of conservation over the roughly million years of eukaryotic evolution. 1, 2 From its origins as a single gene in simpler eukaryotes, the mammalian Coronin gene family has expanded to include at least six members (see Chapter 4).

Increasing evidence indicates that Coronins play critical roles as regulators of actin dependent processes such Cited by: Comprehensive genome analyses across human cancers have revealed that cancer-susceptibility variants often occur in a novel class of genes called long noncoding RNAs (lncRNAs).

lncRNAs have recently attracted significant interest as clinical biomarkers due to their dramatically altered expression patterns in howtogetridofbadbreath.club: Nadya Dimitrova.

Transcriptional activation of MYC is a hallmark of many B cell lineage neoplasms. MYC provides a constitutive proliferative signal but can also initiate ARF-dependent activation of p53 and apoptosis. The E3 ubiquitin ligase, ARF-BP1, encoded by HUWE1, modulates the activity of both the MYC and the ARF-p53 signaling pathways, prompting us to determine if it is involved in the pathogenesis of Cited by: Coronins have maintained a high degree of conservation over the roughly million years of eukaryotic evolution.1,2 From its origins as a single gene in simpler eukaryotes, the mammalian Coronin gene family has expanded to include at least six members (see Chapter 4).

Increasing evidence indicates that Coronins play critical roles as regulators of actin dependent processes such as cell Cited by: We report here the characterization of a novel mouse model with increased activity for the Ink4a and Arf tumor suppressors.

We have generated a "super Ink4a/Arf" mouse strain carrying a transgenic. Dunckley, R. Parker, in Encyclopedia of Genetics, Biological Role of mRNA Degradation. Messenger RNA stability is an important control point in modulating gene expression for several reasons.

First, the steady-state level of a given mRNA is determined by a balance between its rates of synthesis and degradation. Soufir N, Lacapere JJ, Bertrand G, Matichard E, Meziani R, Mirebeau D, Descamps V, Gerard B, Archimbaud A, Ollivaud L, Bouscarat F, Baccard M, Lanternier G, Saiag P, Lebbe C, Basset-Seguin N, Crickx B, Cave H, Grandchamp B () Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to howtogetridofbadbreath.club: Ketty Peris, Maria Concetta Fargnoli.

ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions.

ANRIL has been shown to regulate its neighbor tumor suppressors Cited by: Seven different CDKN2A germline mutations were identified in 17 patients (%). In total, we identified 15 CDKN2A exon 2, one exon 1α missense mutation, and one exon 1β frameshift mutation.

The age of onset was significantly lower and the number of primary melanomas higher in patients with howtogetridofbadbreath.club by: To date, the results have shown that xenograft models do not accurately predict the clinical efficacy of anti-tumor drugs.

Therefore, a question arises as to whether spontaneous and/or genetically-engineered mouse models for lung cancer would be more useful as tools for pre-clinical drug howtogetridofbadbreath.club by: 5.

Genetic Profiling: Searching for Novel Genetic Aberrations in Glioblastoma, Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer, César López-Camarillo and Elena Aréchaga-Ocampo, IntechOpen, DOI: /Author: Pouya Jamshidi, Clark C.

Chen. Pancreatic Cancer and Tumor Microenvironment. Editors. Paul J. Grippo Hidayatullah G. Munshi The Robert H. Lurie Comprehensive Cancer Center of Northwestern University Chicago, ILUSA.

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Supported by the Special Statutory Funding Program for Type 1 Diabetes Research. INTRODUCTION. ARF (p14 ARF in humans, p19 ARF in mice), the product of an alternative open reading frame of the ARF/INK4a locus (Quelle et al., ), is a tumor-suppressor protein that is mutated or inactivated in a significant number of human tumors (Sherr, ).One of the best-defined functions of ARF is to control the p53/MDM2-dependent checkpoint in response to oncogenic signals.

Dr Tim Fenton is a Senior Lecturer in molecular biosciences. His research interests are in understanding the molecular changes that occur as cancers develop and evade destruction by our immune system.

His goal is to apply these findings to enable earlier diagnosis and more effective therapy. What is a gene, post-ENCODE.

History and updated definition Mark B. Gerstein,1,2,3,9 Can Bruce,2,4 Joel S. Rozowsky, 2Deyou Zheng, Jiang Du,3 Jan O. Korbel,2,5 Olof Emanuelsson,6 Zhengdong D. Zhang,2 Sherman Weissman,7 and Michael Snyder2,8 1Program in Computational Biology & Bioinformatics, Yale University, New Haven, ConnecticutUSA; 2Molecular.

haematologica Journal of the Ferrata Storti Foundation. Table of Contents VolumeIssue 9: September Cover Figure Bone marrow smear showing atypical mast. Nov 04,  · Jong MT, Gray TA, Ji Y, Glenn CC, Saitoh S, Driscoll DJ, Nicholls RD () A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region.

Hum Mol Genet – PubMed Google ScholarCited by: 1. Primary mouse embryonic fibroblasts (MEFs) lacking the ARF tumor suppressor contain abnormal numbers of chromosomes.

However, no role for ARF in cell division has previously been proposed. Here we demonstrate a novel, pindependent role for ARF in the mitotic checkpoint. Consistent with this, loss of ARF results in aneuploidy in vitro and in.

Sep 21,  · EWS-FLI1 fusion type, p53 mutation, and homozygous deletion of p16/p14ARF have each been shown to be prognostically significant in Ewing sarcoma (ES). We provide the first combined prognostic analysis of these three molecular parameters in howtogetridofbadbreath.club by: Jul 08,  · Read "c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention, Cancer Letters" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

1 INTRODUCTION. Evidence from the fossil record indicates that urodeles (salamanders and newts) of the Permian period (the last period of the Paleozoic era, ∼ million years ago) were capable of limb regeneration (Fröbisch, Bickelmann, & Witzmann, ).How the urodeles evolved the ability to regenerate limbs is a matter of speculation (Brockes, ).Cited by: Aug 01,  · Read "Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors, Cancer Genetics and Cytogenetics" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at.

Sep 11,  · Yesim Gökmen-Polar, PhD, obtained her PhD in Molecular Genetics in Turkey and then obtained postdoctoral training in Memphis, Galveston and howtogetridofbadbreath.club is currently a Research Assistant Professor of Pathology and Laboratory Medicine.

Under the tutelage of George Sledge, MD (past president of ASCO), she has obtained extensive experience in the field of developmental Cited by: May 01,  · The application of techniques in molecular biology to human neurosurgical conditions has led to an increased understanding of disease processes that affect the brain and to novel forms of therapy that favorably modify the natural history of many of these howtogetridofbadbreath.club by: It also provides a vivid details how centurions led their lifestyle.

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We developed a zebrafish model of brain tumours based on somatic expression of oncogenes that activate MAPK and PI3K signalling in neural progenitor cells and found that HRASV12 was the most effective in inducing both heterotopia and invasive howtogetridofbadbreath.club by: Oct 06,  · The development of xenograft models was a big step in moving toward more clinically relevant tumor models.

24,25 Since the first report of the successful xenografting of a human cancer cell line into nude mice innumerous studies have been conducted using the xenograft mouse model as a tool to answer a variety of questions regarding the cause, prevention, and therapy of various Cited by: Oct 01,  · A K-ras model of pancreatic cancer shows that in an Ink4a/Arf heterozygous background, the primary tumors have increased genomic complexity than those on an Ink4a/Arf −/− background (Bardeesy et al., ), suggesting that a less biased model leads to greater genetic instability, as seen in human cancers, and is therefore a more accurate.

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Trends Cogn Sci. May;7(5) Ink4a/Arf -/-and HRAS Clinical characterization of gastric lesions initially diagnosed as low-grade adenomas on forceps biopsy. Dig Endosc, immunohistochemistry for TFE3 and CD and of reverse transcription polymerase chain reaction for ASPSCR1-TFE3 fusion transcript. Abstract.

Tumors of bone and soft tissue represent a heterogeneous group of biologically and clinically diverse neoplasms. Cytogenetic analysis has identified two broad groups ofCited by: 1. Dmp1 is a tumor suppressor protein that activates p14ARF-p53 pathway via direct binding to the p14ARF promoter.

Her2/neu and Ras oncogenes induce Dmp1 expression leading to Arf-pdependent cell cycle arrest. Human DMP1 locus is hemizygously deleted in ∼50% of breast carcinomas, which is mutually exclusive of INK4a/ARF or p53 inactivation. ), we expected pro-apoptotic genes to be repressed. Surprisingly, however, senescent IMR90 showed an upregulation of prominent pro-apoptotic “initiators” PUMA and BIM while the anti-apoptotic “guardian” BCL-2 was reduced (Figures 1A and S1A).This suggested senescent IMR90 are primed to undergo apoptosis but that the execution of the death program is howtogetridofbadbreath.club by: May 13,  · Correspondingly, melanomas arising in Ink4a/Arf heterozygotes sustained a consistent loss of the wild type Ink4a/Arf allele.

Finally, on an Ink4a/Arf−/− background, transgenic animals developed spontaneous cutaneous melanomas with high penetrance after a. Abstract.

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Dev Cell. 47(4): e6, It also indicated that FOXO factors may be one of the nuclear targets of genistein in suppressing tumorigenesis. ARF promotes the MDM2-induced FOXO ubiquitination. ARF is encoded by the INK4a-ARF locus and it is a known inhibitor of the MDM2 E3 ligase function on p